CV & Publications

ABOUT
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CV & PUBLICATIONS
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CURRICULUM VITAE

Education and degrees awarded

2022 Docentship (Associate professorship) in Quantitative Cell Biology (University of Eastern Finland)

2019 Docentship, French National Universities Council (CNU), in Condensed Matter Physics and Materials (CNU 28), Biochemistry and Molecular Biology (CNU 64), Cell Biology (CNU 65) and Fundamental and Clinical Biological Sciences (CNU 87).

2005 Ph.D. in Theoretical Physics, University Bordeaux 1 (France), with A. Buzdin. First-class honors

1997 Bachelor degree in Applied Mathematics, University of Clermont Ferrand 2 (France); rank: 1st ̸ ~250

Previous positions as a researcher

2020-2025 Senior Researcher & Quantitative Cell Biology group leader; Senior Lecturer in computational biomedicine & systems biology, quantitative bio-imaging and modeling; Quantitative spectroscopy expert, Cell and Tissue Imaging Unit (CTIU); Institute of Biomedicine, University of Eastern Finland (UEF, Kuopio)

2015-2020 Research Associate, Systems and Synthetic Biology Unit, Institute for Research in Immunology and Cancerology (IRIC, with M. Tyers), University of Montréal, Canada. Research career stage 3 (independent researcher within the Tyers group.

2014-2015 Research Associate, Wellcome Trust Centre for Cell Biology (with Mike Tyers and E. Schirmer), University of Edinburgh, UK

2011-2014 ARC Foundation for Cancer Research postdoctoral fellow, Cell Growth and Division Laboratory (with D. McCusker), European Institute of Chemistry and Biology (IECB), Bordeaux, France

2009-2011 Postdoctoral Research Associate, Biological Physics group, Division of Molecular Biosciences & Centre for Integrative Systems Biology (with R.G. Endres), Imperial College London (ICL), UK

2006-2008 Postdoctoral Research Associate, Institute for Theoretical Physics (with D. Ivanov), Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland

2002-2005 PhD studentship, Condensed Matter Theory group (with A. Buzdin), U. of Bordeaux, France

Research output

• 36 articles published/in press in peer-reviewed journals; 1 book chapter, 5 peer-reviewed conference proceedings (unpublished data only)

• 933 citations, personal h-factor = 18 (source: google scholar)

• Invited talks/seminars (conferences, workshops, national and international invitations): 24

• Poster presentations (national and international conferences): 27

Research funding

2021-2024 Funding acquisition as sole applicant (for my research group): € 941.677

2021-2024 Funding acquisition as co-applicant (for collaborative research project): €29.150

2023 Funding acquisition as co-applicant (for CTIU): € 655.000

2016-2018 Funding acquisition as a senior scientist under responsibility of group leader (for my research): US$ 787.889 , CA$ 570.000

2012 Funding acquisition for my own salary and research costs: €100.000

Other merits

2022-2025 National coordinator of the Biocentre Finland Biological Imaging education and training network

2018-2025 Supervision of research staff, students and teaching assistants: postdoctoral researchers (4), Ph.D. candidates (2), Master thesis students (4), Master interns (5), Bachelor thesis students (2), Bachelor interns (3), and teaching assistants (7)

2001-2025 Merits in teaching and pedagogical competences: Creation and implementation of various courses at University level (Bachelor-Master-Ph.D., over 1000 h), including funding acquisition for course development, textbook writing, preparation of exercises, practicals and exams …etc. Course topics included quantitative biomedicine, quantitative bio-imaging, mathematics for biomedical students, mathematical modeling of biological systems, computational biomedicine, Matlab computing, phagocytosis, general physics, statistical physics and thermodynamics, hyperfrequencies and digital communication, electronics, optics, electricity and electrotechnics.

2013 Kerner prize for scientific popularization (ARC foundation for Cancer Research, 2nd prize)

PUBLICATIONS

Latest publications
Publications metrics

  1. Karjalainen, K., Tanska, P., Tollis, S., Nieminen, P., Herzog, W., Korhonen, R. K., and Moo, E. K. (2025) Interactions between biomarkers and structure-composition of knee joint cartilage in a rat model of diet-induced obesity and post-traumatic osteoarthritis. Submitted to Ostheoarthritis and Cartilage.
  2. Hanel, A, Abdelsalam, A. and Tollis, S.† (2025). Hematopoietic proliferation is orchestrated by the sequential and lineage-specific activation of Cyclin D, Cyclin E and CDKN sub-modules within the G1/S network. In revision, iScience. https://doi.org/10.1101/2025.05.15.654268
  3. Ehmann, A., Naboulsi, R., Jädersten, M., Tollis†, S., and Herold†, N. (2025) Functionalist Oncology to Model the Contextuality of the Dynamics and Treatment of Acute Myeloid Leukemia. In revision, Scientific Reports
  4. Mustonen, A-M., Julkunen, P., Säisänen, L., Karttunen, L., Esrafilian, A., Reijonen, J., Tollis, S., Käkelä, R., Sihvo, S. P., Höglund, N., Niemelä, T., Mykkänen, A., Mäki, J., Kröger, H., Arokoski, J., and Nieminen, P. (2025) Pain and functional limitations in knee osteoarthritis are reflected in the fatty acid composition of plasma extracellular vesicles. In press, BBA Mol. Cell Biol. Lipids
  5. Goswami, P., Ghimire, A., Coffin, C., Cheng, J., Coulombe-Huntington, J., Ghazal, G., Thattikota, Y., Tyers, M., Tollis, S.†, Royer, C.†(2024) Swi4-dependent SWI4 transcription couples cell size to cell cycle commitment. In press, iScience. (†): corresponding author. https://www.biorxiv.org/content/10.1101/2023.11.29.569332v2
  6. Batnasan, E., Koivukoski, S., Kärkkäinen, M., Sadeesh, N., Tollis, S., Ruusuvuori, P., Scaravilli, M., and Latonen, L. (2024) Platinum-based drugs induce nucleolar and Cajal body stress responses in prostate cancer cells. Cancer cell international 24(1):29.
  7. Mustonen, A.M.†, Palviainen, M., Säisänen, L., Karttunen, L., Tollis, S.†, Esrafilian, A., Reijonen, J., Julkunen, P., Kröger, H., Mäki, J., Arokoski, J., Siljander, P- R-M., and Nieminen, P. (2024) Tetraspanin profiles of serum extracellular vesicles reflect functional limitations and pain perception in knee osteoarthritis. Arthritis Res. Ther. 26: 33. (†):co-corresponding authors
  8. Sun, Y., Taskan, D., Guerra, F., Santhan, S., Coskun, U.C., Liao, S-C. J., Tollis, S. (2024) Tracking protein oligomerization and aggregation in live cells by number and brightness. SPIE Photonics 24, 12847-48
  9. Rizzotto, R., Tollis, S., Pham, N.T., Zheng, Y., Abad, A., Wildenhain, J., Arulanandama, J., Auer, M., Tyers, M., and Schirmer, E.C. (2024) Chemical-genetically interacting estradiol propionate and DHRS7 regulate nuclear size in prostate cancer cell lines. Cells 13(1), 57.
  10. Royer, C.A., Tyers, M., and Tollis, S. (2023) Absolute quantification of protein number and dynamics in single cells. Curr. Opi. Struct. Biol. 82, 102673. 2023.
  11. Höglund, N., Nieminen, P., Mustonen, A.-M., Tollis, S., Holopainen, M., Ruhanen, H., Käkelä, R., Mykkänen, A. (2023) Fatty acid fingerprints in bronchoalveolar lavage fluid and its extracellular vesicles reflect equine asthma severity. Sci. Rep. 13(1), 9821.
  12. Mustonen, A-M., Tollis, S., Käkelä, R., Lehenkari, P., Sihvo, S. P., and Nieminen, P. (2023) Increased n-6 polyunsaturated fatty acids indicate pro- and anti-inflammatory lipid modifications in synovial membranes with rheumatoid arthritis. Inflammation 46(4):1396. doi: 10.1007/s10753-023-01816-3. Online ahead of print
  1. Alexander-Howden, B., Zhang, L., van der Sloot, A.M., Tollis, S., St-Cyr, D., Sicheri, F., Bird, A., Tyers, M. and Lyst, M. (2023) A screen for MeCP2-TBLR1 interaction inhibitors using a luminescence-based assay. Sci Rep 13, 3868.
  1. Schirmer, E.C., Latonen, L., and Tollis, S. (2022) Nuclear Size Rectification: A Potential New Therapeutic Approach to Reduce Metastasis in Cancer. Front. Cell Dev. Biol. 10:1022723.
  1. Tollis, S. (2022)The G1/S repressor WHI5 is expressed at similar levels throughout the cell cycle. BMC Res. Notes 15, 248.
  1. Aaltonen, N., Kyykallio, H., Tollis, S., Capra, J., Hartikainen, J., Matilainen, J., Oikari, S., Heldin, P. and Rilla, K. (2022) MCF10CA breast cancer cells utilize hyaluronan-coated EV-rich trails for coordinated migration. Front. Oncol. 12:869417. doi: 10.3389/fonc.2022.869417
  1. Litsios, A., Goswami, P., Terpstra, H.M., Coffin, C., Vuillemenot, L-A., Rovetta, M., Ghazal, G., Guerra, P., Buczak, K., Schmidt, A., Tollis, S.†, Tyers, M.†, Royer, C.A.†, Milias-Argeitis, A.†, and Heinemann, M.† (2022) The timing of Start is determined primarily by increased synthesis of the Cln3 activator rather than dilution of the Whi5 inhibitor. Mol. Biol. Cell 33(5):rp2. doi: 10.1091/mbc.E21-07-0349.(†):co-corresponding authors
  1. Ould Setti, M.* and Tollis, S.* (2022) In-Depth Correlation Analysis of SARS-CoV-2 Effective Reproduction Number with Mobility Patterns Identifies Three Groups of Countries. J. Prev. Med. Public Health55(2): 134-143.(*): equivalent contributions.
  1. Tollis, S. †,*, Singh, J.*, Thattikota, Y., Palou, R., Ghazal, G., Coulombe-Huntington, J., Tang, X., Moore, S., Blake, D., Bonneil, E., Royer, C.A., Thibault, P., and Tyers, M.† (2022) The microprotein Nrs1 rewires the G1/S transcriptional machinery during nitrogen limitation in budding yeast. PLoS Biol 20(3): e3001548.(*): equivalent contributions. (†):co-corresponding authors; https://doi.org/10.1371/journal.pbio.3001548
  1. Tollis, S. †,*, Rizzotto, A.*, Pham, N., Koivukoski, S., Sivakumar, A., Wildenhain, J., Zuleger, N., Keys, J.T., Batrakou, D., Culley, J., Zheng, S., Lammerding, J., Carragher, N., Brunton, V. G., Latonen, L., Auer, M., Tyers, M., and Schirmer, E.C.† (2022) Chemical interrogation of nuclear size identifies compounds with cancer cell line-specific effects on migration and invasion. ACS Chem. Biol. 17(3), 680–700. (*): equivalent contributions. (†): co-corresponding authors.
  1. Tollis, S., Goswami, P., Palou, R., Coffin, C., Thattikota, Y., Tyers, M. and Royer, C.A. (2022) Growth- and nutrient-dependent G1/S transcription factor upregulation is controlled at the transcriptional level and is critical for proliferation in poor nutrient conditions. Biophysical Journal 121 (3): Pages 404a-405a (peer-reviewed conference proceedings) https://doi.org/10.1016/j.bpj.2021.11.745
  1. Black, L.*, Tollis, S.*,†, Fu, G., Fiche, J.-B., Dorsey, S., Cheng, J., Ghazal, G., Notley, S., Crevier, B., Bigness, J., Nollmann, M., Tyers, M. †, and Royer, C.A. † (2020) G1/S transcription factors assemble in increasing numbers of discrete clusters through G1 phase. J. Cell Biol. 219 (9): e202003041. (*):equivalent contributions.(†):co-corresponding authors.
  1. Jacques, S.*, van der Sloot, A.M.*, Huard, C.*, Coulombe-Huntington, J., Tsao, S., Tollis, S., Bertomeu, T., Culp, E.J., Pallant, D., Cook, M., Bonneil, E., Thibault, P., Wright, G.D., and Tyers, M. (2020) Imipridones cause cellular toxicity in human cells and bacteria by ectopic activation of the ClpP protease. Genetics 214 (4): 1103-1120. (*): equivalent contributions.
  1. Dorsey, S., Goswami, P., Cheng, J., Thattikota, Y., Tollis, S., Royer, C.A., Tyers, M. (2019) Quantification of G1-Cyclin Dynamics in Yeast by Scanning Number and Brightness. Biophysical J 116 (3): page 532 (peer-reviewed conference proceedings).
  1. Dorsey, S.*, Tollis, S.*, Cheng, J., Black, L., Notley, S., Tyers, M., Royer, C.A. (2018) G1/S Transcription Factor Abundance Reveals Growth-Dependent Determinants of Cell Cycle Commitment in Yeast. Cell Systems 6: 1-16. (*): equivalent contributions.
  1. Tollis, S., Dorsey, S., Tyers, M. and Royer, C.A. (2018) Absolute Quantification Reveals Growth and Nutrient-Dependent Control of G1/S Transcription Factor Abundance as a Determinant of Start. Biophysical J. 114 (3): p151a (peer-reviewed conference proceedings).
  1. Black, L., Fiche, J-B., Tollis, S., Cheng, J., Notley, S., Crevier, B., Tyers, M., Nollmann, M. and Royer, C.A. (2018) Super Resolution Imaging of Start Transcription Factors in Yeast. Biophysical J. 114 (3): p547a (peer-reviewed conference proceedings).
  2. Thattikota, Y., Tollis, S., Palou, R., Vinet, J., Tyers, M., and D’Amours, D. (2018) Cdc48/VCP promotes chromosome morphogenesis by releasing condensin from self-entrapment in chromatin. Mol. Cell 69: 1-13.
  1. Laporte, D.,Courtout, F., Tollis, S., Sagot, I. (2016)Quiescent Saccharomyces cerevisiae forms telomere hyperclusters at the nuclear membrane vicinity through a multifaceted mechanism involving Esc1, the Sir complex, and chromatin condensation. Mol. Biol. Cell 27 (12): 1875-1884
  1. Tollis, S. (2015)A Jump Distance-based Bayesian analysis method to unveil fine single molecule transport features. http://arxiv.org/abs/1506.01112
  1. Jose, M., Tollis, S., Nair, D., Mitteau, R., Velours, C., Massoni-Laporte, A., Sibarita, J.B., and McCusker, D. (2015)A quantitative imaging-based screen reveals the exocyst as a network hub connecting endo- and exocytosis. Mol. Biol. Cell 26 (13): 2519-2534
  1. Jose, M.*, Tollis, S.*, Nair, D., Sibarita, J.B., and McCusker, D.(2013)Robust polarity establishment occurs via an endocytosis-based cortical corralling mechanism. J. Cell Biol. 200(4), 407-418. (*): equivalent contributions. Article in Focus in JCB, http://jcb.rupress.org/content/200/4/363/tab-pdf
  1. Mitteau, R., Massoni-Laporte, A., Deepak, M. J., Tollis, S., and McCusker, D. (2012). Mechanisms underlying the regulation of a Rho-family GTPase. Mol. Biol. Cell 23 (conference proceedings).
  1. Tollis, S., Gopaldass, N., Soldati, T., Endres, R.G. (2012) How one cell eats another: principles of phagocytosis. Chapter of the book “Systems microbiology: current topics and applications” by B. Robertson and B. Wren, Caister Academic Press 2012 (ISBN-13: 978-1-908230-02-7)
    https://www.caister.com/hsp/pdf/flyer/systemsmicrobiology.pdf
  1. Dart, A.E., Tollis, S., Bright, M.D., Frankel, G.M., and Endres, R.G. (2012) The motor protein Myosin 1G functions in FcγR-mediated phagocytosis. J. Cell Sci. 125, 6020-6029
  1. Aquino, G., Clausznitzer, D., Tollis, S., Endres, R.G. (2011) Optimal receptor-cluster size determined by intrinsic and extrinsic noise. Phys. Rev. E. 83: 021914
  1. Tollis, S., Dart, A.E., Tzircotis, G., Endres, R.G, (2010) The zipper mechanism in phagocytosis: energetic requirements and variability in phagocytic cup shape. BMC Sys. Biol. 4: 149
  1. Crouzy B., Tollis, S., Ivanov, D.A. (2007) Josephson current in a superconductor-ferromagnet-superconductor junction with in-plane ferromagnetic domains. Phys. Rev. B 76: 134502
  1. Buzdin, A., Tollis, S., Cayssol, J. (2007) Anomalous (H, T) phase diagram in bilayered superconducting systems. Physica C, 460: 1028-1030
  1. Crouzy, B., Tollis, S., Ivanov, D.A. (2007) Josephson current in a superconductor-ferromagnet junction with two noncollinear magnetic domains. Phys. Rev. B 75: 054503
  1. Tollis, S., Cayssol, J., Buzdin, A. (2006) Competition between π-coupling and Fulde-Ferrell-Larkin-Ovchinnikov modulation in a periodic array of ferromagnetic-superconducting bilayers of atomic thickness. Phys. Rev. B 73: 174519
  1. Buzdin, A., Tollis, S., Cayssol, J. (2005) Field-Induced superconductivity with an enhanced and tunable paramagnetic limit. Phys. Rev. Lett. 95: 167003
  1. Tollis, S., Daumens, M., Buzdin, A. (2005) Inversion of the proximity effect in atomic-scale ferromagnet/superconductor/ferromagnet trilayers. Phys. Rev. B 71: 024510
  1. Tollis, S. (2004) First-order phase transitions in ferromagnetic/superconducting/ ferromagnetic trilayers. Phys. Rev. B 69: 104532